Pombo García Lab

Publications

1.8
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1.5
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Screenshot 2025-12-11 192406

2025

 

1. Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates. (Cell)

Yan X, Kuster D, Mohanty P, Nijssen J, Pombo-García K, Garcia Morato J, Rizuan A, Franzmann TM, Sergeeva A, Ly AM, Liu F, Passos PM, George L, Wang SH, Shenoy J, Danielson HL, Ozguney B, Honigmann A, Ayala YM, Fawzi NL, Dickson DW, Rossoll W, Mittal J, Alberti S, Hyman AA.Cell. 2025 Jul 24;188(15):4123-4140.e18. doi: 10.1016/j.cell.2025.04.039. Epub 2025 May 23.PMID: 40412392

2. Quantitative imaging of lipid transport in mammalian cells. (Nature)

Iglesias-Artola JM, Böhlig K, Schuhmann K, Cook KC, Lennartz HM, Schuhmacher M, Barahtjan P, Jiménez López C, Šachl R, Garikapati V, Pombo-Garcia K, Lohmann A, Riegerová P, Hof M, Drobot B, Shevchenko A, Honigmann A, Nadler A.Nature. 2025 Oct;646(8084):474-482. doi: 10.1038/s41586-025-09432-x. Epub 2025 Aug 20.PMID: 40836094
 

2024

 

3.  Membrane prewetting by condensates promotes tight-junction belt formation. (Nature)

Pombo-García K, Adame-Arana O, Martin-Lemaitre C, Jülicher F, Honigmann A.Nature. 2024 Aug;632(8025):647-655. doi: 10.1038/s41586-024-07726-0. Epub 2024 Aug 7.PMID: 39112699 
 
 

2023

 

 
 
4. Rational optimization of a transcription factor activation domain inhibitor
 
Basu S, Martínez-Cristóbal P, Frigolé-Vivas M, Pesarrodona M, Lewis M, Szulc E, Bañuelos CA, Sánchez-Zarzalejo C, Bielskutė S, Zhu J, Pombo-García K, Garcia-Cabau C, Zodi L, Dockx H, Smak J, Kaur H, Batlle C, Mateos B, Biesaga M, Escobedo A, Bardia L, Verdaguer X, Ruffoni A, Mawji NR, Wang J, Obst JK, Tam T, Brun-Heath I, Ventura S, Meierhofer D, García J, Robustelli P, Stracker TH, Sadar MD, Riera A, Hnisz D, Salvatella X.Nat Struct Mol Biol. 2023 Dec;30(12):1958-1969. doi: 10.1038/s41594-023-01159-5. Epub 2023 Dec 4.PMID: 38049566 

2022

 

 
 
5. Biomolecular condensates in epithelial junctions.
 
Sun D, LuValle-Burke I, Pombo-García K, Honigmann A.Curr Opin Cell Biol. 2022 Aug;77:102089. doi: 10.1016/j.ceb.2022.102089. Epub 2022 Jun 10.PMID: 35696872 

2021

 

 
6. Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions.
 
Beutel O, Maraspini R, Pombo-García K, Martin-Lemaitre C, Honigmann A.Cell. 2019 Oct 31;179(4):923-936.e11. doi: 10.1016/j.cell.2019.10.011.PMID: 31675499